Highcitee – Awesome giorno giovanna shirt

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The cruel intersection of a global pandemic and an agitating, still-contested election has not been kind to migraine sufferers. With our stress levels climbing higher than ever, cases of these severe headaches have risen accordingly, says Emad Estemalik, M.D., who leads the Cleveland Clinic’s headache division. “Heightened stress, triggered by the amount of time we spend navigating through news and social media, translates to more screen time and eyestrain that can certainly increase headache frequency,” Estemalik confirms. If someone gets three to five headache days per month, he says, pandemic-related stress can bump that to 10 to 15 days.

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And the blows just keep coming. As the Migraine Trust reports, of the one in seven adults who suffer from migraines globally, women are disproportionately affected, and three times more likely to be impacted by them than men. More than just throbbing temple pain, the often debilitating neurological disease with a broad range of symptoms—including nausea, dizziness, sensitivity to noise, light, and scents, and visual disturbances—can last for hours, or days, and currently there is no cure. But there is some good news, says Christopher Gottschalk, M.D., chief of general neurology at Yale University School of Medicine and one of the country’s leading migraine specialists. According to Gottschalk, we are in the midst of “an extraordinary period” of revolutionary ideas, devices, and medications for migraine sufferers. “For 25 years, what I’ve had to say to people is, ‘Here, try this. Hope it helps. Good luck. It may cause side effects. If you keep getting headaches, well, I really can’t do much about it.’ Now,” he says, “we can give somebody a shot and say, ‘In a month, you will probably be better. And in two months you’ll probably be even better than that.’” Gottschalk laughs. “It still shocks me that I can say all those words in the same sentence.” Here, a breakdown of the new ways to find relief from pervasive headaches, politically induced or otherwise.

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Until recently, many drugs used by doctors for migraines were developed for other conditions, such as epilepsy. But in the past few years, the FDA has approved several new classes of targeted, effective drugs developed specifically for migraines. Even better, they have markedly fewer side effects than commonly used tryptamine-based drugs, also known as triptans, which have been prescribed since the early ’90s to relieve headaches but often come with major side effects such as nausea, insomnia, or hair loss. CGRP inhibitors, medications that block calcitonin gene-related peptide—a protein released by the brain during migraine attacks (and “a very ugly, cumbersome name,” says Gottschalk)—are among the most promising. Three of these prescription-only drugs—Aimovig, Ajovy, and Emgality—are taken monthly with an EpiPen–like shot; a fourth, Vyepti, is administered via I.V. by a doctor every three months. “These drugs produce great results, in much less time, with almost no side effects,” Gottschalk confirms. Nurtec and Ubrelvy, which are gepants—another new class of FDA-approved medication that also targets CGRP molecules—are formulated to turn off migraines in progress rather than prevent them. “They don’t have quite as much bang for the buck as, say, an injection of [the commonly used triptan] sumatriptan,” says Gottschalk. “But they’re well tolerated and can do a great job.”

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